One of probably the most promising areas for arthritis remedy is using autologous grownup mesenchymal stem cells. These are progenitor cells (cells that may differentiate into different cells) which might be current throughout the affected person.
Most descriptions of using mesenchymal stem cells have come from evaluations of sufferers with osteoarthritis. While most of those experiences have been largely anecdotal, one latest presentation from our middle revealed our expertise with 22 sufferers with osteoarthritis of the knee (American College of Rheumatology assembly, November, 2010, Atlanta, Georgia).
The findings had been fairly encouraging. Among different joints we’ve evaluated embody the shoulder in addition to the hip. Further investigation is deliberate for joints reminiscent of the bottom of the thumb, ankle, and the bottom of the massive toe.
What is extraordinarily thrilling is a latest report from RNL BIO, a biopharmaceutical firm specializing in using donor grownup stem cell therapeutics.
They described a affected person report using stem cell remedy on an orthopedic backbone surgeon who suffered from autoimmune arthritis.
According to the press launch, “Dr. Stanley Jones, the surgeon and affected person, experiences that he had a sudden onset of acute ache in his wrist in September 2009; shortly thereafter the affected person skilled ache in his knees as properly. Dr. Jones noticed a rheumatologist who identified him with autoimmune arthritis. He was positioned on cortisone, a steroid hormone, to suppress immune response and alleviate ache. Unfortunately Dr. Jones suffered issues from the cortisone… His situation deteriorated and his potential to carry out routine actions of every day dwelling or his career was impacted.
… After a workup, he acquired stem cell infusions in Kyoto, Japan in May 2010. Post infusion, he started to note enchancment and by the tip of 5 months, he had a whole restoration and was capable of resume sports activities in addition to working.”
While the precise prognosis relating to this affected person’s arthritis is unknown, the scientific presentation suggests the prognosis of rheumatoid arthritis.
The main distinction between using autologous mesenchymal progenitorcells in treating osteoarthritis and treating different types of arthritis is pretty important.
In treating osteoarthritis, we use a mix of development components and a tissue scaffold to be able to maintain the stem cells in place in order that they’ll develop new cartilage.
The state of affairs described above with utilizing donor autologous mesenchymal stem cells makes use of their potential as immunomodulators.
These cells have been utilized in autoimmune illness reminiscent of lupus.
According to the NIH, “the objective of hematopoietic stem cell therapy for lupus is to destroy the mature, long-lived, and auto-reactive immune cells and to generate a new, properly functioning immune system”….
“The affected person’s personal stem cells have been utilized in a process referred to as autologous hematopoietic stem cell transplantation. First, sufferers obtain injections of a development issue, which coaxes giant numbers of hematopoietic progenitor cells to be launched from the bone marrow into the blood stream. These cells are harvested from the blood, purified away from mature immune cells, and saved. After enough portions of those cells are obtained, the affected person undergoes a routine of cytotoxic (cell-killing) drug and/or radiation remedy, which eliminates the mature immune cells. Then, the hematopoietic stem cells are returned to the affected person through a blood transfusion into the circulation the place they migrate to the bone marrow and start to distinguish to turn into mature immune cells.