Stem Cell Treatment May Help Ease Osteoarthritis Pain, Offer Alternative To Knee Replacement

stem cell nutritionLast yr, Patricia Beals was advised she’d want a double knee alternative to restore her severely arthritic knees or she’d most likely spend the remainder of her life in a wheelchair.

Hoping to keep away from surgical procedure, Beals, 72, opted as a substitute for an experimental therapy that concerned harvesting bone marrow stem cells from her hip, concentrating the cells in a centrifuge and injecting them again into her broken joints.

“Almost from the moment I got up from the table, I was able to throw away my cane,” Beals says. “Now I’m biking and hiking like a 30-year-old.”

A handful of medical doctors across the nation are administering therapies just like the one Beals obtained to cease and even reverse the ravages of osteoarthritis. Stem cells are the one cells within the physique capable of morph into different forms of specialised cells. When the affected person’s personal stem cells are injected right into a broken joint, they seem to rework into chondrocytes, the cells that go on to provide contemporary cartilage. They additionally appear to amplify the physique’s personal pure restore efforts by accelerating therapeutic, lowering irritation, and stopping scarring and lack of operate.

Christopher J. Centeno, M.D., the rehab drugs specialist who carried out Beals’ process, says the outcomes he sees from stem cell remedy are outstanding. Of the more-than-200 sufferers his Bloomfield, Colo., clinic handled over a two-year interval, he says, “two thirds of them reported greater than 50 percent relief and about 40 percent reported more than 75 percent relief one to two years afterward.”

According to Centeno, knees reply higher to the therapy than hips. Only eight p.c of his knee sufferers opted for a complete knee alternative two years after receiving a stem cell injection. The full outcomes from his medical observations will likely be printed in a significant orthopedic journal later this yr.

The Pros and Cons

The greatest benefit stem cell injections appear to supply over extra invasive arthritis cures is a faster, simpler restoration. The process is completed on an outpatient foundation and the vast majority of sufferers are up and transferring inside 24 hours. Most put on a brace for a number of weeks however nonetheless can get round. Many are even capable of do some light stationary biking by the top of the primary week.

There are additionally fewer problems. A buddy who had knee alternative surgical procedure the identical day Beals had her therapy developed life-threatening blood clots and could not stroll for weeks afterwards. Six months out, she nonetheless hasn’t made a full restoration.

Most surgical procedures do not go so awry, however nonetheless: Beals simply returned from a week-long biking journey the place she coated 20 to 40 miles per day with out a lot as a tweak of ache.

As for dangers, Centeno maintains they’re nearly nonexistent.

“Because the stem cells come from your own body, there’s little chance of infection or rejection,” he says.

Not all medical consultants are fairly so enthusiastic, nevertheless. Dr. Tom Einhorn, chairman of the division of orthopedic surgical procedure at Boston University, conducts analysis with stem cells however doesn’t use them to deal with arthritic sufferers. He thinks the thought is fascinating however the science will not be there but.

“We need to have animal studies and analyze what’s really happening under the microscope. Then, and only then, can you start doing this with patients,” he says.

The few research accomplished to this point have examined how stem cells heal traumatic accidents moderately than degenerative situations reminiscent of arthritis. Results have been promising however, as Einhorn factors out, the required restore mechanisms in every circumstance are very completely different.

Another draw back is value: The injections aren’t accredited by the FDA, which suggests they don’t seem to be coated by insurance coverage. At $four,000 a pop — all out of pocket — they definitely aren’t low cost, and lots of sufferers require multiple shot.

Ironically, one factor driving up the worth is FDA involvement. Two years in the past, the company stepped in and stopped physicians from intensifying stem cells within the lab for a number of days earlier than placing them again into the affected person. This means all procedures should be accomplished on the identical day, no stem cells could also be preserved and most of the costlier elements of the therapy should be repeated every time.

Centeno says similar day therapies usually aren’t as efficient, both.

But regardless of the sky-high price ticket and lack of proof, sufferers like Beals imagine the therapy is nothing wanting a miracle. She advises anybody who’s a candidate for joint alternative to contemplate stem cells first.

“Open your mind up and step into it,” she says. “Do it. It’s so efficient.

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