Adult Stem Cell Therapy And Heart Failure, 2018 To 2018: A Systematic Review

Adult Stem Cell Therapy and Heart Failure, 2000 to 2016: A Systematic Review.

stem cell enhancer supplementJournal:
JAMA Cardiol

Publication Year:
2016

Authors:
Patricia Ok Nguyen
June-Wha Rhee
Joseph C Wu

PubMed hyperlink:
27557438

Funding Grants:
Human Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure
Macaca mulatta as superior mannequin for predictive preclinical testing of engineered cardiac autografts and allografts

Public Summary:
Stem cell remedy is a promising remedy technique for sufferers with coronary heart failure, which accounts for greater than 10% of deaths within the United States yearly. Despite greater than a decade of analysis, additional investigation continues to be wanted to find out whether or not stem cell regenerative remedy is an efficient remedy technique and will be routinely applied in scientific observe. OBJECTIVE: To describe the progress in cardiac stem cell regenerative remedy utilizing grownup stem cells and to focus on the deserves and limitations of scientific trials carried out up to now. EVIDENCE REVIEW: Information for this evaluate was obtained by means of a search of PubMed and the Cochrane database for English-language research printed between January 1, 2000, and July 26, 2016. Twenty-nine randomized scientific trials and seven systematic opinions and meta-analyses had been included on this evaluate. FINDINGS: Although grownup stem cells had been as soon as believed to have the flexibility to create new coronary heart tissue, preclinical research recommend that these cells launch cardioprotective paracrine elements that activate endogenous pathways, resulting in myocardial restore. Subsequent randomized scientific trials, most of which used autologous bone marrow mononuclear cells, have discovered solely a modest profit in sufferers receiving stem cell remedy. The lack of a major profit could outcome from variations in trial strategies, discrepancies in reporting, and an overreliance on surrogate finish factors. CONCLUSIONS AND RELEVANCE: Although stem cell remedy for heart problems shouldn’t be but prepared for routine scientific utility, vital progress continues to be made. Physicians must be conscious of the present standing of this remedy in order that they’ll higher inform their sufferers who could also be searching for different therapies.

Scientific Abstract:
Importance: Stem cell remedy is a promising remedy technique for sufferers with coronary heart failure, which accounts for greater than 10% of deaths within the United States yearly. Despite greater than a decade of analysis, additional investigation continues to be wanted to find out whether or not stem cell regenerative remedy is an efficient remedy technique and will be routinely applied in scientific observe. Objective: To describe the progress in cardiac stem cell regenerative remedy utilizing grownup stem cells and to focus on the deserves and limitations of scientific trials carried out up to now. Evidence Review: Information for this evaluate was obtained by means of a search of PubMed and the Cochrane database for English-language research printed between January 1, 2000, and July 26, 2016. Twenty-nine randomized scientific trials and seven systematic opinions and meta-analyses had been included on this evaluate. Findings: Although grownup stem cells had been as soon as believed to have the flexibility to create new coronary heart tissue, preclinical research recommend that these cells launch cardioprotective paracrine elements that activate endogenous pathways, resulting in myocardial restore. Subsequent randomized scientific trials, most of which used autologous bone marrow mononuclear cells, have discovered solely a modest profit in sufferers receiving stem cell remedy. The lack of a major profit could outcome from variations in trial strategies, discrepancies in reporting, and an overreliance on surrogate finish factors. Conclusions and Relevance: Although stem cell remedy for heart problems shouldn’t be but prepared for routine scientific utility, vital progress continues to be made. Physicians must be conscious of the present standing of this remedy in order that they’ll higher inform their sufferers who could also be searching for different therapies.

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